Integrins protect sensory neurons in models of paclitaxel-induced peripheral sensory neuropathy
In this study, live imaging and superresolution approaches provide evidence that paclitaxel treatment causes cellular changes that are consistent with alterations in endosome-mediated trafficking of integrins. Furthermore, paclitaxel-induced changes in recycling endosomes precede morphological degeneration of nociceptive neuron arbors and could be prevented by integrin overexpression
This was a collaboration between Cellular Imaging and the labs of Wesley Grueber and Francesca Bartolini.
This project used the W1 Spinning Disk Confocal for imaging sensory neuron morphology and the W1-SoRa Spinning Disk Confocal for superresolution imaging of intracellular organelles. Custom image analysis was developed in Cellular Imaging using Fiji and Python.